Angelman syndrome

Angelman syndrome is a genetic disorder that causes developmental delay and neurological problems. Infants appear typical at birth but often have feeding problems and exhibit developmental delays by 6 to 12 months. Seizures often begin between 2 and 3 years of age. Speech impairment is pronounced. Individuals often display hyperactivity, small head size, sleep disorders, and movement and balance disorders. Angelman syndrome results from absence of a functional copy of the UBE3A gene inherited from the mother. There is no specific therapy for Angelman syndrome. Medical therapy for seizures is usually necessary. Physical and occupational therapies, communication therapy, and behavioral therapies are important in allowing individuals to reach their maximum developmental potential.

Services and Programs

Family Outreach Center and Disability Services
Disability-specific programs associated with the Vanderbilt Kennedy Center and other organizations at Vanderbilt provide a broad range of treatment, research, technical assistance, education, and outreach services.
Alphabet Therapy Workshop: Children with Angelman Syndrome Can Learn!!
The Alphabet Therapy Project of Vanderbilt University has trained therapists in 5 states who would love to work with your child.
Best Buddies
Best Buddies Colleges pairs people with intellectual disabilities in one-to-one friendships with college students.

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Printable Resources and Materials

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Links and Resources

Angelman Syndrome Foundation (ASF)
ASF's Mission is to advance the awareness and treatment of Angelman Syndrome through education and information, research, and support for individuals with Angelman Syndrome, their families and other concerned parties.
Foundation for Angelman Syndrome Therapeutics (FAST)
Organization of families and professionals dedicated to finding a cure for Angelman Syndrome and related disorders through the funding of an aggressive research agenda, education, and advocacy. The Foundation is committed to assisting individuals living with Angelman Syndrome to realize their full potential and quality of life.

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Upcoming Events

March, 02 2010 - Registration Required
Alphabet Therapy Workshop, Australia
April, 01 2010 - Registration Required
Alphabet Therapy Workshop, United Kingdom

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StudyFinder - Participate in a study related to Angelman syndrome

Vanderbilt Kennedy Center researchers need subjects to complete the studies listed below.

Telling our Story: Angelman syndrome Natural History Study

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Video, Podcast and Images

Video: Phenotypic Characterization in Angelman Syndrome Using Advanced Imaging Techniques
Seminar highlights the results of recent work in Angelman Syndrome using advanced neuroimaging techniques to examine how brainbased changes relate to the clinical/ cognitive/behavioral profiles (e.g., language, cognition, social relatedness, repetitive behaviors) in individuals with AS. The implications for clinical management are presented.

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