Vanderbilt Kennedy Center

Research and Disability Topics

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Angelman syndrome

Angelman syndrome is a genetic disorder that causes developmental delay and neurological problems. Infants appear typical at birth but often have feeding problems and exhibit developmental delays by 6 to 12 months. Seizures often begin between 2 and 3 years of age. Speech impairment is pronounced. Individuals often display hyperactivity, small head size, sleep disorders, and movement and balance disorders. Angelman syndrome results from absence of a functional copy of the UBE3A gene inherited from the mother. There is no specific therapy for Angelman syndrome. Medical therapy for seizures is usually necessary. Physical and occupational therapies, communication therapy, and behavioral therapies are important in allowing individuals to reach their maximum developmental potential.


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Services and Programs

  • Family Outreach Center
    Disability-specific programs associated with the Vanderbilt Kennedy Center and other organizations at Vanderbilt provide a broad range of treatment, research, technical assistance, education, and outreach services.
  • Tennessee Kindred Stories of Disability
    Families, friends and service providers share their stories about people living with disability in Tennessee.

Printable Resources and Materials

  • Angelman Syndrome Foundation (ASF)
    ASF's Mission is to advance the awareness and treatment of Angelman Syndrome through education and information, research, and support for individuals with Angelman Syndrome, their families and other concerned parties.
  • Best Buddies (Vanderbilt Chapter)
    Vanderbilt University's Best Buddies chapter.
  • Foundation for Angelman Syndrome Therapeutics (FAST)
    Organization of families and professionals dedicated to finding a cure for Angelman Syndrome and related disorders through the funding of an aggressive research agenda, education, and advocacy. The Foundation is committed to assisting individuals living with Angelman Syndrome to realize their full potential and quality of life.
  • Management of Angelman Syndrome
    A clinical guideline by the Angelman Syndrome Guideline Group, hosted by Dyscerne.

Video, Podcast and Images

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