Last Updated: Monday, February 24, 2014
Principal Investigator: Paul Newhouse, M.D.
Other researchers: Elizabeth Dykens, PhD
In the general population, memory changes may be an early warning sign of dementia. In adults with Down syndrome, preclinical signs of dementia can begin as early as the mid-30s and include behavioral or personality changes (depressive symptoms, withdrawal, indifference, passivity).
A recent study conducted in our lab found significant improvements in adults diagnosed with Mild Cognitive Impairment (MCI) who used nicotine patches. The patches were effective and had an excellent safety profile. We hope to find similar positive effects in adults with Down Syndrome. During the visits, there will be a physical exam, some thinking and memory tasks, and an fMRI. A parent and/or guardian should accompany the adult.
This treatment research study represents a collaboration between Vanderbilt’s Center for Cognitive Medicine, directed by Paul A. Newhouse, M.D. & the Vanderbilt Kennedy Center, directed by Elisabeth Dykens, Ph.D. It is supported by a Nicholas Hobbs Society Discovery grant.
Non-smoking adults with Down Syndrome 25 years and older who have experienced mild changes in memory, concentration or behavior
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6 study visits