Paul Newhouse directs the Vanderbilt Center for Cognitive Medicine. This multidisciplinary laboratory is focused on human research studies that investigate the biological, neurochemical, and brain circuitry mechanisms that underlie changes that occur in cognitive functioning associated with pathological development, normal aging, and gender-related differences using cognitive psychology, neuropharmacology, and functional magnetic resonance imaging (fMRI). Of particular interest is cognitive impairment that is secondary to the development of complex neuropsychiatric disorders, including Alzheimer's disease, as well as neurodevelopmental disorders such as attention deficit hyperactivity disorder (ADHD).