Aaron Bowman's lab utilizes a combined approach of molecular genetics, biochemistry, and cell and developmental biology to understand the gene-environment interactions underlying neurodegenerative diseases. The lab employs a diverse range of model systems, including patient-derived induced pluripotent stem cells (iPSCs), neuronal culture, and mouse models of Huntington's disease, Down syndrome/Alzheimer's disease, and other diseases. Bowman's lab aims to define mechanisms of neuronal dysfunction and understand the basis of selective neuropathology by characterizing the molecular function of disease genes and their interaction with environmental agents under both normal and pathological conditions. They are primarily studying interactions between metal and other toxicant exposures and neurodegenerative disease states.