To study the control of neural progenitor cell differentiation, we have generated animal models of TSC that inactivate the mouse Tsc1 gene in various progenitor cell populations. These models target dorsal Emx1 progentors or ventral Dlx5/6 progenitors to inactivate the Tsc1 gene in glutamatergic neurons/glia and GABAergic interneurons respectively. In addition to mouse models, we are also generating novel models using human induced pluripotent stem cells to study the role of the TSC genes during differentiation and the production of many neural and non-neural lineages.
- Tsc1 Emx1 CKO mice
- Tsc1 Dlx5/6 CKO mice
- Tsc2 CKO
- induced Pluripotent Stem (iPS) Cells